Kadry A Elbakry, Nahed A Omar and Shaymaa M Nasr
Background: The liver and kidneys play apivotal role in the metabolism of nutrients, drugs, hormones, metabolic waste products and thereby maintaining body homeostasis. The present study was planned to demonstrate the favorable hepatonephroprotective effect of honey or propolis against CCl4 histopathological, histochemical and immunohistochemistry.
Material and methods: Rats were randomly divided into 4 groups: The first group of 10 rats serves as control. The second were maintained as CCl4, then third and fourth maintained as honey and propolis respectively for period of experiment (6 weeks). Pieces of liver and kidney were subjected to histopathological and immunohistochemistry procdures and the obtained sections (5 μm thick) were stained with H&E also with silver nitrate stain and anti laminin antibody for immuno- histochemistry.
Result: Marked histopathological alteration were observed in the studied sections under the influence of CCl4, the most common changes were cloudy swelling of hepatocytes, fatty changes, clear vacuolation of renal cells and congested blood vessels. After treated with honey and propolis showed improvement of hepatocytes and renal tissues.
Conclusion: This study indicated that CCl4 has a toxic effect on liver and kidney. Honey and propolis improve the structural integrity of the cell membrane and ameliorates histopathological, histochemical and immunohistochemistry changes.
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