Transplantationstechnologien und Forschung

Risk Factors of Thrombosis of Pancreatic Graft: A Review

Abstract

Farhan Asghar, Jun Hu, Shijie Zhong, Hanlin Yao, Zongze Qi, Yong Hou, Yunfei Luo and Hong Zhu

One of the most common diseases that can affect human beings is Diabetes Mellitus. To that, Pancreas transplantation is the best known treatment so far but it also has some limitations. One of the most common reasons for failure is Thrombosis of pancreatic graft after transplantation. This review paper offers a brief history of transplantation and summary of those factors which can cause thrombosis of a pancreatic graft. There are two major groups for these factors; a) pre transplantation and b) post transplantation risk factors. The existing literature on thrombosis of pancreatic graft highlights those critical factors which could be one of the causes for thrombosis in a pancreatic graft. Pre transplantation risk factors include age of donor and recipient, gender of recipient, medical history of donor and recipient, ABO identity, duration of cold ischemia, administration of steroids and liquid of conservation. On the other hand, post-operative factors for thrombosis of pancreatic graft include venous anastomosis, microcirculation of graft, post-operative Von willebrand factor, post-operative hyperinsulinemia and type of pancreas transplantation. This review offers guidelines for pancreas transplantation in the light of these pre transplantation and post transplantation risk factors, so that surgeons can reduce the risk of thrombosis in a pancreatic graft.