Nuklearmedizin und Strahlentherapie

The Value of 18F-FDG PET/CT in Detecting Local Recurrence or Distant Metastases in Patients with Renal Cell Carcinoma Who Underwent Radical Nephrectomy

Abstract

Ai-ka Abneh Awad *and Attieh Ola

Aim: The aim of this study is to detect the value of 18F-FDG PET/CT in detecting local recurrence or distant metastases in patient who underwent radical nephrectomy for renal cell carcinoma.

Materials and Methods: This retrospective study includes 88 patients diagnosed to have renal cell carcinoma underwent radical nephrectomy. Both 18F-FDG PET/CT and CT scan were done in the post-operative period for follow up. Sites of the relapse were categorized into local recurrence and distant metastasis. The final diagnosis of disease status was made on subsequent follow up by conventional imaging CT and 18F-FDG PET/CT with histopathology confirmation for all of the cases.

Results: PET/CT was positive and detected recurrence in 48/88 patients, of which confirmed to be recurrence via biopsy 46/48 and was negative in 40/88 patients, 3 of them were falsely negative. 11/48 had local renal bed recurrence and 35/48 patients had distant metastases. PET/CT classified: 46/48 of cases to be true-positive, 2/48 false-positive and 3/40 false-negatives. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 93.9%, 94.9%, 94.3%, 95.8%, and 92.5%, respectively.

Conclusion: 18F-FDG PET/CT scan proved its efficiency in post-surgical renal cell carcinoma patients as a follow up tool in local recurrence and distant metastasis. In particular detection of renal bed recurrence and bone metastasis. This can be considered as a base for future studies with larger population number.