Zeitschrift für diabetische Komplikationen und Medizin

The Relationship between Mean Platelet Volume and HbA1c in Patients with Diabetes Mellitus: A Controversial Topic

Abstract

Athena D. Myrou*, Styliani A. Spanou, Christina P. Michael, Maria C. Christodoulou and Christos G. Savopoulos

This text pertains to the connection between Mean Platelet Volume (MPV) and diabetes mellitus, a widespread health issue. Elevated MPV levels have been linked to various diseases, including cardiovascular diseases and diabetes-related complications. Research has shown that MPV levels are higher in patients with uncontrolled diabetes than in those with controlled diabetes; multiple theories have been proposed to explain this observation. The relationship between MPV and glycated hemoglobin (HbA1c) levels is a subject of debate, with some studies showing no association, while others have demonstrated a correlation between the two. The scientific community has focused on investigating MPV as an inflammatory marker of diabetes mellitus and obesity. MPV may serve as a useful diagnostic tool for detecting thrombotic complications in conjunction with Platelet Distribution Width (PDW). Elevated MPV levels have also been associated with an increased risk of metabolic syndrome, particularly in males, older individuals, overweight individuals and those with poor glycemic control. MPV levels are higher in patients with microvascular complications such as retinopathy and nephropathy.