Zeitschrift für klinische Forschung

Ibie Leave (Mucuna flagellipes) Decreased Anxiety Like Behaviour in Swiss White Mice Following Long Term Consumption

Abstract

Amah AK, Aduema W and Amah UK

The use of Mucuna flagellipes in recent time has been on the increase as a result of its speculated therapeutic effect. Owing to the fact that there are no detailed reports on Mucuna flagellipes or any report on its effect on anxiety and fear, this work is therefore intended to investigate the possible effects of this herb on anxiety and fear in Swiss white mice, using the elevated plus maze as experimental apparatus. Twenty CD-1 mice were divided into two groups (1-2, n=10). Group 1 (Control) was administered normal fed while group 2 was the treated group. Data were analyzed using statistical tools (one way ANOVA and Student t-test). Results revealed anxiety like behavior treated mices when compared to the control. However, administration of the Ibie Leave (Mucuna flagellipes) reduced anxiety related behavior in mice. In summary, it is therefore a strong consideration that Mucuna flagellipes (Ibie leaf) contains compounds and other constituents which could be responsible for the anxiolytic properties and effects which the leaf had on the mice thereby reducing fear and anxiety related behavior.