Humangenetik und Embryologie

Epigenetics and Hematopoietic Stem or Progenitor Cells

Abstract

Yang Wang, Benjamin T. Moore, Xianhao Peng and Peng Xiao

The maintenance and differentiation of hematopoietic stem/progenitor cells (HSPCs) is a critical process of hematopoiesis that includes the formation of lymphoid lineage and myeloid lineage. Epigenetic regulation is mainly composed of DNA methylation, histone modifications, non-coding microRNA (miRNA) regulation and chromatin remodeling, which are essential for the maintenance and differentiation of hematopoietic stem/progenitor cells (HSPCs). This review details the epigenetic studies of four major epigenetic mechanisms in normal and aberrant HSPCs, as well as hematopoiesis.