Zeitschrift für Onkologie, Medizin und Praxis

The increasing reliance on digital technologies and interconnected systems in radiation oncology practices has introduced new vulnerabilities and risks associated with cyber security attacks. These attacks can have severe consequences, including compromising patient data, disrupting critical treatment processes, and causing financial losses. Therefore, it is crucial for radiation oncology practices to implement robust cyber security measures to safeguard their operations and protect patient information. This paper presents a comprehensive overview of the strategies and best practices for protecting radiation oncology practices from cyber security attacks. It explores the unique challenges and vulnerabilities specific to this field, such as the interconnectedness of treatment planning systems, electronic medical records, and medical devices. The paper discusses the potential consequences of cyber threats and emphasizes the importance of proactive risk assessment and mitigation.

Urological cancers, including prostate, bladder, and kidney cancers, pose a significant healthcare challenge worldwide. To address this challenge, effective research and clinical management require comprehensive and accurate data collection. However, traditional manual data collection methods are time-consuming, error-prone, and limited in their ability to handle large-scale datasets. In this paper, we present the Cancer Research Uro-Oncology Database (CRUOD), a novel automated system designed to streamline the collection and management of uro-oncology data. CRUOD leverages advanced technologies such as natural language processing, machine learning, and cloud computing to automate data extraction, standardization, and storage processes.

This paper explores the lessons learned from mentoring in radiation oncology from a remote setting. It discusses the challenges faced by mentors and mentees in maintaining effective communication, establishing trust, and fostering professional development in a virtual environment. The paper highlights the importance of leveraging available technologies and platforms to facilitate mentorship activities, such as video conferencing, online learning platforms, and virtual tumor boards. Drawing from experiences and best practices, the paper provides practical recommendations for successful remote mentoring in radiation oncology. It emphasizes the need for structured mentorship programs, clear communication channels, and goal-oriented mentoring relationships. Strategies for promoting engagement, building mentor-mentee rapport, and ensuring continued professional growth are explored.

The purpose of establishing Clinical Quality Registries (CQRs) was to compare clinical outcomes between hospitals or regions within a nation. The purpose of this study was to identify these CQRs for gynaecological oncology, to summarize their characteristics, processes, and QIs, and to determine whether it would be feasible to conduct future international comparisons in order to obtain a global overview of these CQRs.

Overall Survival (OS) is regarded as the most trustworthy and preferred endpoint in oncology trials to evaluate drug treatment benefits. In order to speed up and streamline the development of clinical oncology drugs, it is critical to identify the dynamic effects and connections between the various variables collected from patients for a given drug and its indication. Due to temporal differences, drug-induced effects and causal relationships can be difficult to interpret. Parametric time-to-event models and population pharmacokinetic– pharmacodynamic modeling are increasingly being used to address this issue.

Heterochromatin Protein 1α (HP1α) is a critical player in chromatin organization and gene regulation, and its dysregulation has been implicated in various cellular processes, including cell proliferation and cancer development. This review focuses on the role of HP1α as a characteristic of cell proliferation that is pertinent to clinical oncology. Extensive research has demonstrated that HP1α plays a dual role in regulating cell proliferation. On one hand, it functions as a transcriptional repressor, modulating the expression of genes involved in cell cycle control and DNA replication. On the other hand, HP1α has also been found to interact with numerous signaling pathways and transcription factors, thereby promoting cell proliferation under certain conditions. Aberrant expression and localization of HP1α have been observed in various types of cancer, including breast, prostate, lung, and colorectal cancer. Furthermore, studies have shown that altered HP1α expression is associated with poor prognosis and resistance to conventional therapies in cancer patients. Understanding the molecular mechanisms underlying HP1α's involvement in cell proliferation is of significant interest in clinical oncology. Targeting HP1α and its associated pathways may offer promising therapeutic opportunities for cancer treatment. In addition, HP1α expression levels and subcellular localization can potentially serve as diagnostic and prognostic biomarkers in clinical practice.

A core of several tetraspanin proteins organizes other membrane proteins like growth factor receptors, integrins, and Human Leukocyte Antigen (HLA) antigens in these complexes. Albeit most tetraspanin proteins have been concentrated separately, tetraspanin proteins and their edifices can affect cell grip and motility, associations with stroma or influence announcing development factors, and for the greater part of them no ligand has been distinguished. Although they are found in all cell types, these proteins have primarily been studied functionally in lymphoid cells. Tetraspanins have been identified as metastasis suppressors in some tumors, but their significance is still unclear. Data are also available for these tumors. They are outlined, along with some of their implications for tumor biology and areas that require additional research. The biological properties of tumor cells, particularly those pertaining to tumor adhesion and dissemination, can be significantly affected by membrane proteins that are involved in cellular interactions with other cells or the stroma as well as signaling pathways. The tetraspanins, a brand-new class of membrane proteins, are beginning to gain importance in cell biology but have received very little attention in the context of cancer biology up until this point.