Klinische Infektionskrankheiten: Open Access

The respiratory syndrome that results from the coronavirus disease 2019 is accompanied by a cytokine storm, the release of numerous proinflammatory factors, and other symptoms. The Delta variant, which has been associated with a high mortality risk, has taken over in many nations. Therefore, comprehension of the immune responses linked to COVID-19 lineages may help in the creation of therapeutic and diagnostic approaches. The severity of COVID-19 was correlated with innate and adaptive immunological factors and pathways, according to numerous single-cell gene expression studies. Additional research on the features of the host-pathogen response to infection caused by various lineages is needed. Here, we used single-cell transcriptome profiling to identify variant-specific molecular immune factors in venous mononuclear cells from people with various COVID-19 and virus lineage severity. Our research shows that the Delta lineage of SARS-CoV-2 is associated with a large population of monocytes with distinct gene expression signatures, which may suggest immune components for targeted therapy.

Warfarin is an oral anticoagulant, which is commonly prescribed in hospital settings in various thrombotic conditions. It is known to have had a broad range of interactions with other medicinal gents widely used during clinical settings, particularly antibiotics, resulting in altered coagulation parameters and bleeding in such patients. In this study, we intend to describe two such cases that developed excessive hypoprothombinemic response due to cefoperazone and improved after substituting cefoperazone with alternative antibiotic. While there is no conclusive proof of warfarin-cefaperazone interactions, it is recommended that healthcare providers explore alternate antibiotic use in warfarin therapy patients and allow careful surveillance of the coagulation profile for all those patients receiving warfarin and antibiotics in combination with warfarin dosage modification.