Zeitschrift für Onkologie, Medizin und Praxis

The Clinical Outcome of Wilms Tumour: A 6-Years-Experience of King Fahad Specialist Hospital, Dammam

Abstract

Omar H, Salah Abdelbaki H and Alharbi Q

Introduction: Wilms’ tumor is the most prevalent renal tumor of childhood that accounts for about 5% of all their cancers. It is also one of the successes of pediatric oncology with long term survival above 90% for localized disease. The aim is to evaluate the disease characteristics and the clinical outcome of children with Wilms’ tumor at King Fahad Specialist Hospital Dammam over six years from 2011 to 2016.

Methods: Our study is a retrospective review of the medical files of children (under 16 years) with Wilms’ tumor who were managed at King Fahad Specialist Hospital Dammam in the interval between January 2011 until December 2016. We analyzed all the Patients’ and disease features, histopathological results, staging, treatment modalities, and outcome, according to the system of the National Wilms Tumor Study Group (NWTSG). Descriptive analysis using frequencies was applied to describe the study variables.

Results: A total of 22 patients, 9 (40.5%) were males and 13 (59.5%) were females (male ratio=M/F=0.69). were identified, with median age of 37.2 months. The majority of the cases were stage III (31.8%), followed by stage 1 (27.3%) Around 70% had favorable histology, 10% had anaplasia, and 20% had mixed pathology. The relapse rate is 18.2%, and the mortality is about 9%, EFS In This Study Was Estimated As 80%, and the OS As 90%.

Conclusion: In a comparison of our results to that of NWTS-5, we noticed that the majority of our patients presented with stage 3, but despite that, the rate of relapse/progressive disease is comparable to international figures, and the overall survival of our patients of 90% is still comparable to the Western experience.