Zeitschrift für Onkologie, Medizin und Praxis

Patients with Locally Advanced Cervical Cancer may be Predicted Treatment Response by Biomarkers

Abstract

Gary Fonseca*

In this study, patients with locally advanced cervical cancer were evaluated for their response to definitive chemo radiation therapy in relation to quantitative metabolic and volumetric FDG PET/CT characteristics. Ninety patients with newly diagnosed locally advanced cervical cancer underwent research. At staging and following treatment, PET/CT was performed on all patients. Patients with and without a complete metabolic response were compared with regard to metabolic and volumetric markers, Total Lesion Glycolysis, and Metabolic Tumor Volume (MTV), of the primary tumour and metastatic lymph nodes. In a subset of FIGO IB2-IIB patients, a similar study was carried out; Results: SUVmax and SUVmean of the primary tumour as well as those of metastatic lymph nodes and TLG were found to be considerably higher than those of the primary tumour. Patients with locally advanced cervical cancer who will not respond to definitive chemo radiation therapy have higher levels of quantitative metabolic and volumetric markers assessed from PET/CT. In particular, MTV and TLG values can be used to predict therapy response in individuals who are not metastatic at staging, which may change the course of treatment.