Alternative und integrative Medizin

Parkinson′s Disease Treatment with Organic Antioxidants: A Review

Abstract

Clare Stephenson

The neurological condition known as Parkinson's disease (PD) is progressive over time. It occurs as a result of the death of dopaminergic neurons. Two pathophysiological pathways for idiopathic Parkinson's disease are reactive oxygen species and complex I, which affects mitochondrial respiratory function. As a result, treating PD with natural antioxidants may offer a different treatment option that slows the disease's progression and avoids oxidative stress. In PD animal and cell line models, this review compares and discusses the outcomes of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea and Hypericum perforatum. The antioxidants under investigation have been shown to protect brain cells from oxidative damage in PD cell and animal models. However, there is always room for improvement and additional research regarding these phytochemicals' therapeutic value.