Journal of Oncology Translational Research

Overexpression of MISP is found in Gastric Cancer and Intestinal Metaplasia

Abstract

Virlliano Thomas

Gastric cancer is one of the most common and deadly cancers worldwide, particularly in East Asia. It has a complex etiology involving genetic, environmental, and lifestyle factors. Among the molecular alterations associated with gastric cancer, the overexpression of certain genes plays a crucial role in tumorigenesis and progression. One such gene that has gained attention is Mitotic Spindle Positioning (MISP). MISP is involved in cell division and mitotic spindle positioning, which are critical for maintaining genomic stability. Recent studies have indicated that MISP overexpression may be linked to gastric cancer and its precursor lesion, intestinal metaplasia. This essay explores the role of MISP in gastric cancer and intestinal metaplasia, discussing its biological function, the evidence supporting its overexpression in these conditions, and the potential implications for diagnosis and treatment.