Clinical Gastroenterology Journal

Non-Healing Gastric Ulcer in a Patient with Rheumatoid Arthritis

Abstract

Tharani Sundararajan, Krati Chauhan, Rakesh Mandal, Zafar Quader and Ramprasad Jegadeesan

Leflunomide has been reported to impair ulcer healing by inhibiting DNA synthesis. To the best of our knowledge, we report a first case of non-healing gastric ulcer in a patient treated with leflunomide for rheumatoid arthritis. Patient developed gastric ulcer secondary to NSAID use which did not heal for several years despite being on PPI therapy and avoiding NSAIDs. Gastric ulcer healing was documented after stopping leflunomide.