Klinische Infektionskrankheiten: Open Access

Molecular Epidemiology of Multi-drug Resistant Tuberculosis in High-burden Regions

Abstract

Torres Ruiz

Tuberculosis (TB) remains a significant global health challenge, particularly in high-burden regions. The emergence of Multi-Drug Resistant Tuberculosis (MDR-TB) complicates treatment strategies and exacerbates public health concerns. Molecular epidemiology provides critical insights into the transmission dynamics, genetic diversity and resistance mechanisms of MDR-TB, enabling more targeted and effective interventions. Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite significant advances in medicine and public health, TB remains a major global health concern, particularly in low- and middle-income countries. Understanding the epidemiology, diagnosis, treatment and prevention of TB is crucial for effective control and eventual eradication of this disease. TB is one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent, ranking above HIV/AIDS.