Zeitschrift für Pharmakognosie und Naturprodukte

Investigations of Anthelmintic Activity of Ethanolic Leaf Extract of Premna esculenta

Abstract

Jannatul Ferdous Shaily1, Syeda Jakia Sultana1, Pritesh Ranjan Dash2* and Taslima Akter3

The establishment of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the assessment of medicinal plants as an alternative source of anthelmintic using the P. posthuma mature earthworm. The timing of the earthworms paralysis and death at (25, 50, and 100 mg/ml) of three different concentrations was investigated. There was dose-dependent action in the plant extract, however, the ethanolic extract showed more than the aqueous extract. Albendazole was used as a standard reference at the same concentration as an extract, and normal saline served as the control. As compared to the conventional reference drug albendazole, compared to pure water, albendazole (10 mg/ml) is utilized as the standard reference medication. This is revealed by the results of the current study.