Zeitschrift für klinische und medizinische Genomik

Integration of Glutamate Dehydrogenase and Nanoporous Gold for Electrochemical Detection of Glutamate

Abstract

Myles Carlie

Glutamate is a crucial neurotransmitter in the central nervous system, playing a pivotal role in various physiological processes. Accurate detection of glutamate levels is essential for understanding its role in health and disease. Electrochemical detection methods have gained significant attention due to their sensitivity, selectivity, and rapid response. This article reviews the integration of Glutamate Dehydrogenase (GDH) and Nano porous Gold (NPG) for electrochemical detection of glutamate. GDH serves as a biorecognition element, facilitating selective glutamate detection, while NPG offers a high surface area and excellent conductivity for enhancing sensitivity. This review discusses the principles, recent advancements, challenges, and future prospects of this integrated approach for glutamate detection.