Journal of Hypertension: Open Access

Hypertension in Pregnancy: The Role of Circulating Endothelial Progenitor Cell Dysfunction

Abstract

Alexander E Berezin

Pregnancy-induced hypertension (PIH) development associates well with considerable abnormalities in the structure and function of vascular endothelium. Lowered number and weak function of circulating endothelial progenitor cells (EPCs) as a marker of worsening endothelial integrity were recognized a promising indicator of PIHrelated clinical outcomes. Although there are limiting data regarding predictive usefulness of serial EPC count measurement in pregnant women, it has been postulated that EPC dysfunction could be got better prognostication than other biomarkers including serum inflammatory cytokines, von Willebrand factor, E-selectin in prediction of some severe PIH-related states, i.e., fetoplacental insufficiency and premature parturitions. The sort communication is depicted the role of EPC dysfunction as a promising biomarkers in PIH.