Zeitschrift für Formulierungswissenschaft und Bioverfügbarkeit

Healthy Volunteers to Assess Amino Acid Plasma Profiles from a Prolonged′Release Protein Replacement

Abstract

Huang Tian

In a previous article, we described how Confocal Raman Spectroscopy was used to look at the topical transport of active ingredients and excipients. Also, we have compared the outcomes of with those of in vitro diffusion tests on human skin. To yet, however, has only been applied as a semiquantitative technique for estimating chemical absorption via the skin, with outcomes reported as arbitrary signal intensity units. This obviously presented difficulties for determining skin distribution and evaluating the medication bioavailability and bioequivalence of topical preparations utilising.The penetration of niacin amide from different formulations in human skin was examined in the current study both in vivo and in vitro utilising a quantitative approach and limited dosage circumstances.