Zeitschrift für Formulierungswissenschaft und Bioverfügbarkeit

Effects of Poloxamers as Excipients on Electrospun Polycaprolactone (PCL) Fibres′ Physicomechanical Properties, Cellular Biocompatibility and In Vitro Drug Release

Abstract

Erina Sihih

Electrospinning is a versatile technique used to fabricate nanofibrous structures with a wide range of applications, including tissue engineering and drug delivery systems. Polycaprolactone (PCL) is a commonly used polymer in electrospinning due to its biocompatibility, biodegradability, and mechanical properties. However, PCL alone may not possess the desired properties for certain applications. To enhance the functionality of PCL fibres, the addition of excipients such as poloxamers has been explored. Poloxamers are triblock copolymers that exhibit unique physicochemical properties, including thermosensitivity, surfactant properties, and biocompatibility. This article aims to explore the effects of poloxamers as excipients on the physicomechanical properties, cellular biocompatibility, and in vitro drug release of electrospun PCL fibres.