Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells
Abstract
Cristiane Fernandes de Assis, Raniere Fagundes Melo-Silveira, Ruth Medeiros de Oliveira, Leandro Silva Costa, Hugo Alexandre de Oliveira Rocha, Gorete Ribeiro de Macedo and Everaldo Silvino dos Santos
Chitooligosaccharides exhibit biological activities, including antitumor, antimicrobial and antioxidant. In this study we used a mixture of chitooligosaccharides produced by enzymatic hydrolysis in two tumor cell lines and assessed the cell proliferation and cytotoxicity of these compounds. The proliferation of HeLa cells was inhibited around by 60%.
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