Zeitschrift für Informatik und Systembiologie

Computational Study of Viral Segments Inserted within the Regions of Human Genome

Abstract

P. Pandarinath, M. Shashi and A. Appa Rao

Humans have been carrying unwanted viral gene segments since many years and reports suggests that approximately 3-8% of the human genome has been comprised of viral DNA. In this point of view, various viral sequences were downloaded from NCBI Tax Browser and scanned against complete genome of Homo sapiens for the presence of possible viral inserts in human genome. The results from the computational analysis revealed that dengue virus resulted in viral segments inserted in the intron regions of human genome and exon region insertions were observed with polio and simian enterovirus. The alignments which show > 25-30 residues, 90-100% identities and the sequences located in the exon regions were considered.