Entwicklung und Anwendungen von Biokeramik

Characteristics of Silver-Hydroxyapatite/PVP Nanocomposite

Abstract

Amany Mostafa, Hassane Oudadesse, Yann Legal, Enas Foad and Guy Cathelineau

Metal nanoparticles play an important role in many different areas such as catalysis, electronics, sensors, and cancer therapy. Silver, in its many oxidation states (Ag0, Ag+, Ag2+, and Ag3+), has long been recognized as having an inhibitory effect towards many bacterial strains and microorganisms commonly present in medical and industrial processes. Silver was introduced in various materials including hydroxyapatite due to its biocompatibility. The unique size-dependent properties of nanomaterials make them superior and indispensable. In this work, nanohydroxyapatite/polyvinylpyrrolidone composite was doped with 2 different concentrations of silver nanoparticles prepared by reduction method. Several techniques like TEM, XRD, FT-IR, and SEM with EDS were used to characterize the prepared samples. The bioactivity test (soaking in SBF) at different short time intervals was characterized by using inductively coupled plasma-optical emission spectroscopy (ICP-OES) method. It is demonstrated that silver-doped nanohydroxyapatite obviously improves the bioactivity of the apatite at the early stages of immersion. The antibacterial inhibition over 3 types of bacteria (Staphylococcus aureus, Streptococcus mutans, and Pseudomonas) is under investigation.