Journal of Hypertension: Open Access

Assessing the Mechanisms of Pseudohyperaldosteronism-Induced Hypertension and Hypokalemia by Clinically used Azole Antifungals: A Bioassay and Molecular Modeling Study

Abstract

Lucija Telisman

Pseudohyperaldosteronism, also known as apparent mineralocorticoid excess syndrome (AME), is a rare genetic disorder that causes the body to produce excessive amounts of cortisol, leading to hypertension and hypokalemia. In some cases, certain medications, including azole antifungals, can also induce pseudohyperaldosteronism-mediated hypertension and hypokalemia. Hypertension, or high blood pressure, is a common condition affecting millions of people worldwide. While there are many factors that can contribute to hypertension, including lifestyle and genetic factors, pseudohyperaldosteronism-induced hypertension is caused by the overproduction of cortisol. Cortisol is a hormone produced by the adrenal glands that helps regulate the body's response to stress. When cortisol levels are too high, it can cause the body to retain sodium and excrete potassium, leading to fluid retention and increased blood pressure