Virologie: Aktuelle Forschung

Background: SARS-CoV-2 virus infection poses significant global health challenges and considered a global epidemic sweeping all countries of the world which prompted scientists around the world to search for a quick or safe treatment to preserve people's lives. So far, options for controlling and treating the disease have not been revealed. The current study was conducted to evaluate the effectiveness of pomegranate peels extract against the SARS-CoV-2 virus in the laboratory.

Methods: In this research, two methods of extraction are carried out ethyl alcohol and distal water extract of pomegranate peels. Activity of the extract assessed using 50% Tissue Culture Infectious Doses (TCID50) method in vero E6 cells.

Results: Pomegranate peels extract had the highest inhibitory effect against SARS- CoV-2 virus with IC50 values of 0.125 μl, 0.0625 μl and 0.031256 μl in vero E6 cells.

Conclusion: Based on our results, the aqueous extract of pomegranate peels can inhibit SARS-CoV-2 virus replication in vitro.

It is important to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to ease the symptoms, the liver stage to stop deteriorations, and the transmission stage to defend other humans. The tube for the blood stage is flattering healthy, but this should not be a source of satisfaction, as the current treatments set a high standard. Drug discovery labors directed close the liver and transmission phases are in their beginning but are getting increasing care as directing these stages could be contributory in eliminating malaria.

The authors peer into the future, after COVID-19 has passed (if ever). The growing human population remains the top concern-what systems analysts call a ‘wicked’ challenge and not soon resolvable. Returning to 2019 or doing nothing at all will not work obliging us to adopt a duo of interlinked strategies. First, reduce pressures on the environment; second, mend our socioeconomic habits, envisaging a world that was not before. Changes must be significant. We discuss eventual mechanisms to support the United Nations in efforts to make sustainability the key characteristic of our future on planet Earth. The wastrel’s reckless ways must cede to reason. How life is lived will decide if Homo sapiens can keep its home on Earth—or even continue to exist. Courage should prove key to a saner future. This may require the casting of new forms of multi-scale governance of our highly interrelated hyper-network at the level of Earth system. We also consider new arrangements for leadership such as multi-nation options, a regional setup, or a multilateral organizational scheme such as the UN’s. Further, paradigm change is suggested, linked to basic reform of the UN itself, various schemes for transformative change, a democratic world parliament or a cohabitation model. A Great Reset mechanism for the time during and after COVID-19 should there be such an era may facilitate the deep changes we need. In sum, profound reflections over the right developmental trajectory are essential for our future in ‘our’ time: the Anthropocene.