Zeitschrift für chirurgische Pathologie und Diagnose

Mitochondrial function is essential to meet energy demand and to coordinate cellular function. Mitochondria are often referred as the powerhouse of the cell, but besides converting nutrients that we eat into energy that can be used by the cell, mitochondria also play an important role in intercellular signaling.

I am glad to introduce the HILARIS’s Journal of Surgical Pathology and Diagnosis Volume 3 Issue 1. During the calendar year 2020, all issues of volume 2 were published online well within the time and the print issues were also brought out and dispatched within 30 days of publishing the issue online.

Journal of Surgical Pathology and Diagnosis is an open-access Peer-Reviewed journal that seeks to publish the latest and excellent research papers, reviews and letters in all fields related to the subjects of Pathology. Submissions will be assessed on their scientific validity and merit

Hilaris has been a pioneer in online open access publications to the international audiences in several areas of science where researchers all over the world publish their research discoveries and novel findings. As it is mentioned in the website, ‘Journal of surgical pathology and diagnosis’ focuses on areas such as cytopathology techniques, molecular diagnostics such as DNA/ RNA analysis for detection of infectious agents.

Tumor Budding

Tumor budding is loosely defined by the presence of individual cells and small clusters of tumor cells at the invasive front of carcinomas. It has been postulated to represent an epithelial–mesenchymal transition (EMT).

Tumor budding is a well-established independent adverse prognostic factor in colorectal carcinoma (it is also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine).  Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and fatigue) that may allow for stratification of patients into risk categories more meaningful than those defined by TNM staging, and also potentially guide treatment decisions, especially in T1 and T3 N0 (Stage II, Dukes’ B) colorectal carcinoma. Unfortunately, its universal acceptance as a reportable factor has been held back by a lack of definitional uniformity with respect to both qualitative and quantitative aspects of tumor budding.

Tumor budding is a microscopic finding which basically refers to the process of dissociation of tumor cells at the invasive front of carcinomas and it was shown to be of prognostic significance in previous literature, with respect to lymph node involvement, recurrence and survival . Various methods were employed for the assessment of tumor budding previously, because no definite method, tumor budding cut-off or microscopic field area for its assessment was defined. Due to its prognostic significance, a standardized method was required and this led to 2016 consensus meeting. The aim of the meeting was to standardize the method of assessment of tumor budding.

               In the calendar year 2021, Hilaris is conducting supporting conference to journal. We gladly welcome all the researchers and doctors around the world for the hearing of the foremost recent research and innovations in the field of genetics

                I would also like to express my gratitude to all the authors, reviewers, the publisher, the advisory and the editorial board of JSPD, We appreciate our peer reviewers for taking the time and effort necessary to provide insightful guidance, and we try to show our appreciation to our reviewers.

Pathology is a logical order which includes the investigation of Infections. It supports each part of patient consideration, from symptomatic testing and treatment counsel to utilizing front line hereditary advances and forestalling malady. The entire quintessence of medication lies in Pathology and Microbiology

 Exfoliation syndrome is generally considered an age-related ocular disease that presents with a progressive accumulation of fibrillar aggregates in the human eye. A range of risk factors have been identified that are commonly associated with XFS, including a variety of cellular pathways. However, the exact mechanism of this disease is unknown. In contrast to existing literature, it was recently shown that a variety of structural features exist within these fibrillar aggregates associated with exfoliation syndrome. This hithertofore unknown diversity in fibrillar structures suggests that multiple pathways could exist that contribute to the progression of XFS. Herein, we address these recent findings on the diversity of structural polymorphism observed in fibrils isolated from the lens capsule of various XFS patients and situate this in the context of existing literature on fibrillar structure of these materials. These findings may help to reveal more about the biological functions leading to protein misfolding and aggregation into exfoliation materials.

Postcontact Bleeding (PCB) is defined as bleeding occurring during or immediately after cervical contact as sexual intercourse, vaginal examination and vaginal douches at a time separate from menstruation. It is a common, multifactorial, gynecological symptom.In a review of PCB, the point prevalence of PCB among women in the community ranged from 0.7% to 9%. Occasionally, it is the first presentation of precancerous cervical lesions, and the prevalence of PCB in women with cervical cancer has been reported to vary between 0.7% and 39%.Cervical cytology is used to evaluate women with PCB, and colposcopy is usually performed when there is abnormal cytology.The current management of PCB is not constant. Colposcopy is an important component of the cervical screening program, but there are several disadvantages for patients with PCB undergoing colposcopy screening; for example, patient anxiety and undue distress, use of valuable colposcopy time, and the progression to unnecessary interventions.