Krebswissenschaft und -therapie

Use of Neoadjuvant Chemotherapy and Dissection of the Positive Sentinel Lymph Nodes in the Treatment of Breast Cancer Only on Stage T1 to T2

Abstract

Marcelen Rosenscheg, Adriane Lenhard Vidal and Leonardo Dequech Gavarrete

Objective: breast cancer is the most common cancer in women. Its curative treatment is based on mastectomy, which can be radical or by quadrants. Surgery is done with Axillary Lymph Node Dissection (ALND) in the radical or Sentinel Lymph Node Dissection (SLND) in the condom. In this sense, this article evaluates the displacement of surgery with positive sentinel in patients with Neoadjuvant Chemotherapy (NAC) and radiotherapy compared to standard or radical treatment. Methods: this is a retrospective study based on the analysis of the medical records of Hospital São Vicente de Paulo (HSVP) in Guarapuava-PR from 2011 to 2020. Patients with early stage breast cancer, with maximum stage IIIA, were selected. quadrantectomy, NAC and positive sentinel lymph node biopsy.

Results: The results showed recurrence in 2 patients in the control group (7%) and in one patient in the study group (17%) which resulted in subsequent death.

Conclusion: Although this research was small, some subjective results were identified, as is the case of patients with standard breast cancer treatment, in the intermediate stage, post-menopause and positive lymph nodes in the biopsy, who demonstrated a better response to treatment when compared to with other patients. . In addition, young patients had a worse response compared to others. However, more comprehensive studies with longer follow-up are needed to draw meaningful conclusions.