Zeitschrift für chirurgische Pathologie und Diagnose

Understanding Atypical Ductal Hyperplasia and Lobular Neoplasia

Abstract

Stephanie Angela*

Atypical ductal hyperplasia and lobular neoplasia are two types of proliferative breast lesions that are considered to be precursors to breast cancer. ADH is characterized by abnormal proliferation of cells within breast ducts, exhibiting architectural and cytological features that are concerning for malignancy but fall short of meeting criteria for carcinoma. LN, on the other hand, involves abnormal cell growth within lobules, often presenting with distinctive histological patterns. Both ADH and LN are associated with an increased risk of subsequent development of invasive breast carcinoma. This review aims to provide a comprehensive understanding of ADH and LN, focusing on their histopathological features, clinical significance, risk factors, and management strategies. Diagnostic challenges and controversies surrounding these lesions will also be discussed, along with recent advancements in molecular profiling techniques that offer insights into their biological behavior and potential for progression to invasive disease.