Hadi Khoshmohabat, Alireza Makarem, Mohammad Yasin Karami, Hamid Reza Rasouli, Zahra Danial, Golnoosh Mahmoodizade, Rohallah Rezaei, Shahram Paydar, Seyede Niloofar Dastgheib, Seyed Ali Hossein Zahraei and Zahra Shayan
Background: The useful surgical hemostasis agent using in patients with grade 4 of the liver laceration is a challenging problem. This study assessed a topical hemostatic agent (Surgicel) using a partial hepatic laceration hemorrhage model. This experimental study compared the hemostatic effects of Surgicel and conventional gauze packing in hepatic parenchymal bleedings.
Methods: Twenty male Wistar albino rats (weight 250 ± 50 g) were randomly divided into two groups. Within each treatment group, surgicel or gauze packing (GP) (n=10/group) was applied to the liver laceration site that was created in the large lobe of the liver.
Results: There was statistically significant difference between two groups regarding the changes of before and after operation of HCO3 (P=0.019). Across two groups, rats receiving surgicel lost less blood and formed clots more frequently than GP (p<0.001).
Conclusion: Surgicel may be useful to treat hemorrhage from Liver lacerations in trauma patients.
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