Krebswissenschaft und -therapie

Role of Tumor Suppressor Protein p53 in Apoptosis and Cancer Therapy

Abstract

Naga Deepthi CH, VVL Pavan Kumar A, Rameshbabu and U Indirapriyadarshini

TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We here in this review article discusses about the recent advances in p53 research, mainly focusing on apoptosis and therapy for human cancer. Hence, this review aims to update the current related articles and provide a further understanding about such molecular changes relevant to trigger imbalances in the regulation of apoptosis in cancer.