Herz-Kreislauf-Erkrankungen und Diagnose

Resistin Is a Novel Biomarker for a Risk of Heart Failure

Abstract

Yun Bian, Marcy Silver, Jillian Onufrak, Kalon K.L. Ho, Mark A. Marchionni, Peter M Kang, David A Goukassian, Joseph Carrozza, James P Morgan and Xinhua Yan

Resistin is derived mainly from fat tissue in rodents, and serum levels are elevated in animal models of obesity and insulin resistance. Recent clinical studies have demonstrated that circulating resistin is associated with inflammation, coronary atherosclerosis, renal dysfunction, adverse prognosis in patients with atherothrombotic ischemic stroke and heart failure. In the population-based observational study, increased circulating levels of resistin are associated with incidence of new-onset heart failure, even after accounting for prevalent coronary heart disease, obesity, insulin resistance, and inflammation. In the elderly, incident heart failure rates (per 1000 person-years) elevate with increasing baseline resistin concentrations. In addition, resistin is strongly associated with risk for incident heart failure in Cox proportional hazard models controlling for clinical variables, inflammatory biomarkers, and measures of adiposity.