Medizinische Chemie

Pyrazole Derivatives with NCN Junction and their Biological Activity: A Review

Abstract

Farid Abrigach and Rachid Touzani

Pyrazole derivatives have their own importance in aromatic organic heterocycle family. Application of these derivatives in chemistry and biology has attracted increasing interest occupy a unique place in field of medicinal chemistry due to their wide spectrum of biological activities. There are known for their anticancer, antiviral, antibacterial, antifungal, analgesic and anti-inflammatory and activities and so on. Due to the importance of this chemical skeletons, the present review reports the recent progress (2010-2016) on the biological activities of some monodentate, bidentate, tridentate and tetradente compounds based on pyrazole moieties and containing NCN bonds which connecting between the pyrazole and amine unit.