Krebswissenschaft und -therapie

Prognostic Relevance of Ww-Oxidoreductase Gene Expression in Patients with Acute Lymphoblastic Leukemia

Abstract

Walaa Fikry Elbossaty, Camellia Malak and Doaa M.Elghanam

Background: The WWOX gene (WW-Oxidoreductase) gene is frequently lower expressed in variety of tumor.

Methods: Screening for WWOX gene expression was assessed using real-time reverse transcriptase polymerase chain in 50 ALL cases and 50 healthy control.

Results: WWOX gene was significantly lower in ALL cases (0.43239 ± 1.38925) when compared with healthy control (10.501 ± 9.0338) (p=<0.001). No significant differences were found between high and low WWOX gene expression regarding clinical data, age, sex, hematological data. Patients who highly expressed WWOX gene achieved CR at significantly higher rates in ALL (p=0.002), and had significantly lower frequency refractory disease in ALL patients (p=0.017). Higher expression WWOX gene patients have statistically longer OS (p=0.049) when compared with low expression WWOX gene patients.

Conclusion: Our result suggested that WWOX gene was a predictor for better outcome, could be a useful target for immunotherapy and might represent a candidate marker for monitoring of minimal residual disease.