Zeitschrift für biomedizinische und pharmazeutische Wissenschaften

Physiologically Based Pharmacokinetic Modeling

Abstract

Lesli E. Deker

Physiologically based pharmacokinetic modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals. PBPK models strive to be mechanistic by mathematically transcribing anatomical, physiological, physical, and chemical descriptions of the phenomena involved in the complex ADME processes.