Krebswissenschaft und -therapie

Larynx Preserving Treatments in the Early and Advanced Laryngeal Cancers; A Retrospective Analysis

Abstract

Kamian Shaghayegh, Aghili Mahdi and Kazemian Ali

Background To assess tumor control and survival of the patients with laryngeal cancers who received chemoradiation or radiotherapy alone as definitive treatment. Material and Methods Patients with laryngeal cancers who received organ-saving treatment were enrolled in this trial. Results In 147 cases, chemoradiotherapy was administered in 61 patients. Twelve cases were excluded from the analysis because of the treatment interrupt or death. Fifty eight cases had early-staged disease. In median time of follow up (9.9 months), mean overall survival and mean disease free survival were 51 months and 37 months in early lesions, and 30 months and 17 months in locally advanced tumors, respectively. Local control rate was 60% in early-staged and 43.5% in locally advanced cases. The mean total radiation dose significantly affected the tumor control in chemoradiation group. Conclusion It seems that radiotherapy or chemoradiation can be appropriate alternative to total laryngectomy in laryngeal cancers.