Zeitschrift für biomedizinische und pharmazeutische Wissenschaften

Hepato and Renal Protective Effect of Phloretin on Streptozotocin Induced Diabetic Rats

Abstract

Tamilarasan Nithiya, Rajangam Udayakumar

The aim of the present study was to investigate the protective role of phloretin on liver and kidney of streptozotocin (STZ) induced diabetic rats. Phloretin was used at the dose of 25 mg and 50 mg/kg b.w on STZ-induced diabetic rats to analyse the blood glucose, serum insulin, total protein, liver function enzymes and kidney function markers. Significant reduction in the levels of insulin and total protein and elevated levels of blood glucose, kidney function markers such as urea, creatinine and uric acid and increased activities of serum enzymes like alanine amino transferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) were observed in diabetic rats. Treatment of diabetic rats with phloretin ameliorate the elevated levels of glucose, activities of liver function enzymes and kidney function markers and also restore the levels of insulin and total protein to near normal. The results of this study concluded that phloretin have hepato and renal protective effects on STZ-induced diabetic rats. The present findings indicate that phloretin could be considered as therapeutic agents that can ameliorate the progression of diabetic complications.