Neurologische Störungen

Experimental Study on Parkinson Disease Model of Rats

Abstract

Cao Fei, Sun Sheng-Gang, Cao Xue-Bing, Wang Tao, Cheng Ji-Xiang, Mei Yuan-Wu, Tong E-Tang and Luo Fang

Objective: To observe the characteristics of praxiology of Parkinson disease (PD) rats. Methods: At 1d, 7d, 14d after PD rats’ model were successful; we observed the markers of rotational behavior of Parkinson disease (PD) rats. For example: start time, continuous time, maximum turning, etc.
Results: From 1d to 14d, PD rats, start time of the rotational behavior elongated gradually, continuous time shortened by degrees, maximum rotational speed and the number of the rotational behavior were invariable.
Conclusions: Improved method of PD is scientific, reliable, and simple. Substantial nigral pathology of PD rats makes the foundation of the rotational behavior. The injury of substantial nigral can be reflected by maximum rotational speed and the number of the rotational behavior of PD rats.