Umwelt- und analytische Toxikologie

Efficacy and Application of Antidotes in Pediatric Toxicology: A Comprehensive Review

Abstract

Kamshastra Brahman

Drug overdoses and therapeutic misadventures, whether intentional or accidental, are common reasons for presentations to pediatric emergency departments. Timely administration of antidotes is often a critical component of treatment for these patients and can frequently be life-saving. Due to the challenges of conducting randomized controlled trials in clinical toxicology, there is often a lack of information regarding the efficacy and optimal use of antidotes, making it essential to continuously review the literature for new data and evidence. This paper reviews the current evidence and indications for several newer antidotes and treatments for selected common pediatric poisonings, as well as ongoing data regarding the use of a well-known and widely used antidote.