Umwelt- und analytische Toxikologie

Drinking Water Toxicity of Sodium Fluoride in Steroid Producing Glands and Antioxidant Ascorbate Defense System in Albino Rats (Rattus norvegicus)

Abstract

Priyanka Mehta*,Kunwar Bahadur Singh

This investigation examined the reproductive toxic effects and oxidative stress of sodium fluoride (NaF) in male albino rats (Rattus norvegicus). The rats received acute doses of NaF as 0.5 ppm, 200 ppm and 500 ppm through drinking water for 15 days. Additionally 10 mg ascorbate was also supplemented after NaF treatment as an antidote. The dose 0.5 ppm was ineffective and 500 ppm was fatal after 4 days onwards. A significant decrease in ascorbate content of liver and increase in cholesterol content of liver and testes after 200 ppm NaF-15 days treatment was examined but their level from adrenals did not change significantly. Histological studies of testes in these animals indicated atrophy of steroidogenic cells. Almost similar results were obtained when ascorbate was supplemented as an antidote.