Krebswissenschaft und -therapie

Double Minute Chromosomes Associated with Philadelphia Chromosome in Myeloid Leukemia. A Case Study

Abstract

Abolfazl Movafagh, Mostafa Rezaei Tavirani and Mohamad Hasan Heidari

The Philadelphia chromosome was the first consistent cytogenetic abnormality observed in a human cancer. Several characteristic chromosome rearrangements like double minute chromosomes are known to be associated with different subtypes of myeloid leukemia. Double Minute Chromosomes are the cytogenetic hallmarks of genomic rearrangements in cancers. Two cases, one with AML-M1 and the other with CML- blast crisis, associated with double minute chromosomes and Philadelphia chromosome is presented. The additional chromosome changes to primary chromosome abnormality may be influenced by other factor like chemotherapy. The identification of two new cases with co-expression of double minute chromosomes and Ph chromosome presented here for the first time in Iran together with large Mitelman database and other pertinent website reports is discussed.