Zeitschrift für Genetik und Genome

CRISPR/Cas9-Mediated Disruption of Targeted Genes in Gecko Oocytes Induces Biallelic Genomic Mutations

Abstract

Fernando Luis

Researchers are studying the downstream effects of Fgf10 disruption on other genes and signaling pathways involved in limb development. By unraveling these intricate genetic cascades, scientists hope to gain a deeper understanding of the cellular processes and molecular interactions necessary for proper limb formation. The study of biallelic genomic mutations and Fgf10 knockout in gecko embryos offers valuable insights into the genetic basis of limb development. This research has implications not only for understanding the evolutionary significance of limb formation but also for regenerative medicine. Gecko species are known for their extraordinary regenerative capabilities, including the ability to regrow lost limbs. By elucidating the role of Fgf10 and other genes involved in limb development, scientists may unlock new strategies for promoting tissue regeneration and repair in humans.