Krebswissenschaft und -therapie

Correlation between MVD and Two Prognostic Factors: Fuhrman Grade and Tumoral Size, in Clear Cell Renal Cell Carcinoma

Abstract

Colaci Pablo, García Marcela, Errecalde Ana Lía and Inda Ana María

Introduction: Clear cell RCC is the most common type of RCC that occurs in adults and it has the worst prognosis among the common epithelial tumors of these organs. The CD34 is an endothelial antigen that has been used to highlight the microvessel density (MVD) as a direct marker of neoangiogenesis degree.
 
Objective: To establish the correlation between CD34 and other prognostic factors like Fuhrman nuclear degree and tumoral size. Material and methods: Tumour samples from 17 patients with histopathology diagnosis of clear cell RCC were examined by immunohistochemical staining for CD34. The CD34 expression was analyzed by Anova and Student Newman Multiple Comparison Test and Tuckey like post test, and finally we used a Spearman Correlation to compare with the others prognostic factors analysed and Kaplan Meier survival analysis for the disease free survival of the patients.
 
Results and conclusion: There is a negative correlation between the MVD and the Fuhrman nuclear grade, whereas R = -0,46; and p < 0,05 and there is a positive correlation between the MVD and the maximum tumoral diameter, whereas R = 0,47 and p < 0,05. In conclusion, we found that a high MVD is related with a low Fuhrman nuclear grade and a high tumoral size. The possible significance of this study can be that in fact we need more than one parameter to predict the biological behavior of the clear cell CCR.