Krebswissenschaft und -therapie

CD10 and Endothelin-1 are Inversely Expressed in Early Prostate Cancer and Predict Psa Failure after Radical Prostatectomy

Abstract

Panagiotis J. Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, George Moutzouris, Anna Patrikidou, Ioannis A. Voutsadakis, Kassiani Kapatou, Danai D. Daliani, Michael D. Melekos and Christos N. Papandreou

Background: Loss of the membrane endopeptidase CD10 plays an important role in the development of neuropeptide-mediated androgen-independent prostate cancer cell growth. The aim of this study was to investigate the potential prognostic value of the CD10/neuropeptide axis with regard to prostate-specific antigen (PSA) failure after radical prostatectomy in early prostate cancer patients.

Methods: Tumor samples from 70 early prostate cancer patients who underwent radical prostatectomy were immunohistochemically evaluated for expression of CD10 and endothelin-1 (ET-1). The examined parameters were prospectively correlated with time to PSA failure and combined with Gleason grade and pathological TNM stage.

Results: Membranous and apical cytoplasmic expression of CD10 was directly correlated with time to PSA failure ( P < 0.001). Cytoplasmic ET-1 was inversely correlated with time to PSA relapse ( P = 0.002). CD10 and ET-1 were inversely interrelated ( P < 0.001). CD10 expression (P = 0.012) and stage ( P = 0.013) were independent predictors of biochemical recurrence.

Conclusion: CD10 and ET-1 follow inverse patterns of expression in tumors of early prostate cancer patients, in accordance with their biological roles and molecular interrelations. Evaluation of CD10 expression in early prostate cancer might contribute to a better prediction of PSA relapse-free survival after radical prostatectomy.