Krebswissenschaft und -therapie

Bronchial Sialadenoma Papilliferum: A Very Rare Cause of Hemoptysis

Abstract

Roger Fei. Falkenstern Ge, Ott G, Friedel G, Markmann HU, Kohlhäufl M and Kalla J

Purpose: This case is only the third case of the Sialadenoma papilliferum of the bronchial system. This is a extremely rare tumor of the bronchial system. This report highlights once again the histo-pathological difficulties of diagnosing such a rare tumor.

Patients and methods: A 53 year old woman with a 3 weeks history of a productive cough associated with hemoptysis presented to the Community hospital Stuttgart (Teaching Hospital of the University of Tübingen). A thoracic CT revealed a solid mass in the right lower lobe with 10 mm diameter. In the community hospital a bronchoscopic biopsy was suspicious for an adenocarcinoma of the lung.

Result: The patient was transferred to our institution for thoracic surgery and a right lower bilobectomy with semicircular intrapericardial vessel resection and total nodal resection was performed. By immune-histochemical analysis , the removed tumor (size 10 mm) revealed to be a benign adenoma from the seromucosal bronchial glands, which is a very rare benign tumor of the Sialadenoma papilliferum type. All of the removed lymph nodes were analyzed and showed no signs of malignancy.

Conclusion: At present there have been reported only two cases of the pulmonary Sialadenoma papilliferum in the literature. This case report represents the first case of pulmonary Sialadenoma papilliferum in Germany and western Europe. The biologic behavior of this tumor still remains unknown.