Zeitschrift für Bioanalyse und Biomedizin

A Review on LBA and LC-MS Platforms for Supporting Large Molecule Pharmacokinetics Bioanalysis

Abstract

Xiaolong Zhang, Linglong Zou, Weiping Shao and Zhongping Lin, et al.

Over the past ten years, the global market for large molecule therapeutics has rapidly grown for the treatment of a variety of diseases. LBA and LC-MS are two platforms widely used in pharmacokinetic bioanalysis. In this review, we compare LBA and LC-MS and summarize their strengths and limitations. Strategies for platform selection are provided according to the study purpose, study phase, analyte types, assay requirements and other factors.